Protein Localization: Reach out and Touch the Forespore
نویسندگان
چکیده
Bacterial proteins are typically sorted to subcellular regions with distinct physical characteristics that serve as cellular 'addresses', but many proteins are evidently sorted to specific areas that lack any apparent unique identity. Recent work in Bacillus subtilis suggests that such proteins may be localized by interacting with extracellular domains of proteins in an adjacent cellular compartment.
منابع مشابه
Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis.
Endospores of Bacillus subtilis are encased in a thick, proteinaceous shell known as the coat, which is composed of a large number of different proteins. Here we report the identification of three previously uncharacterized coat-associated proteins, YabP, YheD, and YutH, and their patterns of subcellular localization during the process of sporulation, obtained by using fusions of the proteins t...
متن کاملSubcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum.
During the process of spore formation in Bacillus subtilis many membrane proteins localize to the sporulation septum where they play key roles in morphogenesis and cell-cell signalling. However, the mechanism by which these proteins are anchored at this site is not understood. In this report we have defined the localization requirements for the mother-cell membrane protein SpoIVFA, which anchor...
متن کاملSeptal localization of forespore membrane proteins during engulfment in Bacillus subtilis.
In Bacillus subtilis, many membrane proteins localize to the sporulation septum, where they play key roles in spore morphogenesis and cell-specific gene expression, but the mechanism for septal targeting is not well understood. SpoIIQ, a forespore-expressed protein, is involved in engulfment and forespore-specific gene expression. We find that SpoIIQ dynamically localizes to the sporulation sep...
متن کاملSchizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation.
Sporulation of the fission yeast Schizosaccharomyces pombe is a developmental process that generates gametes and that includes the formation of spore envelope precursors called the forespore membranes. Assembly and development of forespore membranes require vesicular trafficking from other intracellular membrane compartments. We have shown that phosphatidylinositol 3-kinase (PtdIns 3-kinase) is...
متن کاملSubcellular localization of proteins involved in the assembly of the spore coat of Bacillus subtilis.
Spores of the bacterium Bacillus subtilis are encased in a two-layered protein shell, which consists of an electron-translucent, lamellar inner coat, and an electron-dense outer coat. The coat protein CotE is both a structural component of the coat and a morphogenetic protein that is required for the assembly of the outer coat. We now show that CotE is located in the outer coat of the mature sp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005